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The Quince ...

 Issue 56
Traveller’s Diarrhoea
Tea increases survival after heart attack

Traveller’s Diarrhoea

As summer draws near a recent Drugs and Therapeutics Bulletin had a piece on travellers diarrhoea.

The definition of traveller’s diarrhoea requires that a person passes three or more unformed stools over 24 hours, with the episode starting during, or shortly after, a period of travel. The diarrhoea is usually accompanied by abdominal pain and faecal urgency, often by nausea and cramps and, occasionally, by fever. Typically, symptoms begin early in a trip (but can occur any time) and last around 4 days.

Around 10% of patients affected have bloody diarrhoea (dysentery). The proportion of travellers from the UK who develop diarrhoea depends on the destination: 20-50% in high-risk destinations (e.g. Africa, South America, some parts of the Middle East and most of Asia); around 20% in intermediate-risk area (e.g. Southern Europe, Israel, Japan, South Africa and some of the Caribbean islands); and fewer than 8% in low risk areas (e.g. North America, Northern Europe, Australia and New Zealand).

In up to 60% of episodes of travellers' diarrhoea, no pathogen is found, because the causative organism is hard to identify, or because the diarrhoea has another cause, such as an unwanted effect of medication (e.g. antimalarials) or a change in eating or drinking habits. The commonest identifiable bacterial cause worldwide is enterotoxigenic Escherichia coli. Other bacterial causes include Shigella spp, Campylobacter jejuni, Salmonella spp. and Aeromonas spp. Protozoa (such as Giardia lamblia and Entamoeba histolytica) viruses (such as rotaviruses) account for a small proportion of cases.

Overall traveller's diarrhoea is common, often disruptive, usually transient and rarely life-threatening. Those going abroad should be told about the importance of personal hygiene and consumption of safe food and water. Antibacterial prophylaxis should only be offered to travellers with serious medical conditions in whom an episode of diarrhoea could be dangerous. Patients with blood diarrhoea, fever or confusion should seek medical advice.

Otherwise, it will normally be sufficient for patients to maintain their fluid and electrolyte intake. Healthy adults can do this by drinking plenty of soups or sugary drinks, whereas young children and elderly people require more careful oral rehydration therapy. An antidiarrhoeal drug is useful for symptomatic relief but carrying such treatment is a reasonable precaution for travellers to remote high-risk areas where medical services are not easily available. Traveller's diarrhoea persisting for more than 14 days requires investigation.

Ref: Drugs and Therapeutics Bulletin

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Tea increases survival after heart attack

This article is included in Quince as a reminder to readers of the excellent service provided by the National Electronic Library of Health which analyses stories from the newspapers and other media. (see link below)

Several newspapers on 7 May 2002 reported that drinking tea is associated with lower mortality after myocardial infarction. The newspaper articles summarise a reasonably well-conducted research study [8] in which it was found that self-reported tea consumption the year before acute myocardial infarction was associated with lower mortality in the following 3-4 years.

The newspaper articles are in general accurate in their reporting of the study. The Daily Mirror, however, mistakenly reports that 44% of heavy tea drinkers died at follow-up, when, in fact, only 14% of this group had died, with only 10% dying from cardiovascular causes.

The research was conducted by Kenneth Mukamal and colleagues at Harvard University. They aimed to determine whether tea consumers have better long-term survival after acute myocardial infarction.

A cohort design was used. The study used data from participants enrolled in the Determinants of Myocardial Infarction Onset Study. Data were collected from chart reviews and face-to-face interviews with 1900 hospitalised patients with confirmed acute myocardial infarction.

A median of 4 days after myocardial infarction, patients were asked about their usual frequency of caffeinated tea consumption during the past year. Based on the distribution of tea consumption within the population, patients' tea consumption was categorised as none, moderate use (less than 14 cups per week), or heavy use (14 or more cups per week).

In December 1995, a median of 3.8 years after recruitment to the study, the National Death Index was searched for the deaths of study participants. Using death certificate information, patient deaths were attributed to either cardiovascular or non-cardiovascular causes.

To determine whether tea consumers have better long-term survival after acute myocardial infarction, the number of cardiovascular deaths in the tea consumption group was examined. The number of cardiovascular deaths was 141 (14%), 67 (11%) and 26 (10%) for non-tea drinkers, moderate consumers, and heavy consumers, respectively. The comparison between tea consumption groups revealed a significant inverse relationship, indicating that a higher level of tea consumption was associated with lower mortality.

This was a reasonably well-conducted study, in which a large sample of patients were assembled at a similar point in their disease progression, groups were comparable on most important known confounding variables, and where they differed there was adequate statistical adjustment for the effects of these variables. In addition, data indicates a dose-response relationship between tea consumption and post-infarction mortality and, importantly, outcome assessors were unaware of each participant's level of tea consumption.

However, this study is weakened by a number of limitations. First, not all potential confounding factors were accounted for in the data collection. For instance, no dietary information was collected for these patients, and it might be the case that tea drinkers eat a healthier diet, or lead healthier lifestyles more generally, and that this difference accounted for differences in post-infarction survival.

Second, since consumption of 14 or more cups of tea per week was relatively uncommon, the study had limited power to define mortality differences between levels of tea consumption.

Finally, it is difficult to determine to what extent the primary factor of interest (tea consumption) was ascertained accurately. Self-report measures, in general, are prone to biased or inaccurate recall of one's own behaviour, and it is unclear therefore to what extent participants were assigned to the appropriate group.

The results should be treated with some caution. There are no systematic reviews on the subject

Ref (web)

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Copyright 2003 | Norman Vetter


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